Zolpidem and cytochrome P450
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چکیده
Some fruit juices and fruits can interact with numerous drugs, in many cases causing adverse. These chemicals inhibit key drug metabolizing enzymes, such as cytochrome P450 3A4 (CYP3A4).. .. Covera HS, Isoptin SR, Verelan); Warfarin (coumadin); Zolpidem (Ambien): Little or no interaction with grapefruit juice. The aim of this study was to identify the form(s) of cytochrome P450 (CYP) responsible for the biotransformation of zolpidem to its alcohol derivatives which, after . Jun 13, 2005. Zolpidem is used for the short-term treatment of insomnia. It works. ... Cytochrome P450 3A4 · Cytochrome P450 1A2 · Cytochrome P450 2D6. Aug 1, 2007. Cytochrome P450 enzymes are essential for the metabolism of many medications.. (Zocor), sildenafil (Viagra), verapamil, zolpidem (Ambien) . Biopharm Drug Dispos. 2002 Dec;23(9):361-7. Effect of zolpidem on human cytochrome P450 activity, and on transport mediated by P-glycoprotein. von Moltke . Nov 27, 2002. Abstract. The influence of high concentrations of zolpidem (100 μM, corresponding to approximately 200 times maximum therapeutic . Jun 12, 2002. Cytochrome P450 (CYP) enzymes was evaluated in a model system using human.
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